BPG致力于知识发现和传播
预出版
2025/9/12 8:04:44 | Browse: 1 | 下载: 0
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
40241 |
| 手稿来源省、自治区或特别行政区 |
上海市 |
| 专业类型 |
消化感染病学 |
| 手稿栏目类型 |
述评 |
| 文章标题 |
慢性乙型肝炎临床治愈的挑战和进展
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| 手稿来源 |
约稿 |
| 所有作者列表 |
刘旭凌, 姜宇朗, 孙明瑜 |
| 基金项目及其编号 |
| 基金项目名称 |
基金编号 |
| 山东省重点研发计划 |
2021CXGC010509 |
| 上海市普陀区杏林优青 |
ptxlyq2301 |
| 上海市普陀区卫生健康系统科技创新项目 |
ptkwws202223 |
| 上海市名中医陈建杰普陀传承工作室 |
ptzygzs2412 |
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| 通讯作者 |
孙明瑜, 博士, 研究员, 201203, 上海市浦东新区张衡路528号, 上海中医药大学肝病研究所. mysun369@126.com |
| 关键词 |
乙型肝炎; 慢性; 临床治愈; 乙型肝炎表面抗原; DNA; 病毒 |
| 核心内容提要 |
慢性乙型肝炎(chronic hepatitis B, CHB)临床治愈又称功能性治愈, 是指停止治疗后血清乙肝表明抗原(hepatitis B surface antigen, HBsAg)和乙型肝炎病毒(hepatitis B virus HBV) DNA持续检测不到、HBeAg阴转、伴或不伴抗抗-HBs出现, 肝脏生物化学指标正常, 肝脏炎症缓解和组织病理学改善等, 但HBV的复制源头共价闭合环状DNA, 可能仍然存在肝细胞核内, 另外宿主因素的免疫耐受以及免疫应答不足, 导致免疫系统无法彻底清除病毒, 即使进行抗病毒治疗也难以实现表面抗原转阴, 导致CHB难以彻底治愈. 那么发现评价疗效或预测反应的新型生物标志物以及开发具有治愈乙型肝炎潜力的新兴抗病毒药物和免疫调节剂以及药物的联合应用将是实现HBV临床治愈有效手段. |
| 引文著录 |
刘旭凌, 姜宇朗, 孙明瑜. 慢性乙型肝炎临床治愈的挑战和进展. 世界华人消化杂志 2025 |
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Received |
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2025-03-28 07:46 |
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Peer-Review Started |
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2025-03-31 00:31 |
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To Make the First Decision |
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Return for Revision |
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2025-05-23 01:51 |
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修回稿 |
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2025-05-30 07:12 |
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Second Decision |
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2025-09-12 06:19 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2025-09-12 08:04 |
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预出版 |
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2025-09-12 08:04 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| Assistant Editor |
吴云晓健 |
| Science Editor |
刘继红 |
| 评议人编号 |
03656599, 03020350, 03743640, 03656580, and 03656412 |
| Editorial Director |
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| Journal Chief Editor |
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| Company Chief Editor |
闫佳萍 |
| Language Editor |
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| Production Editor |
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| Responsible Production Editor |
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| Responsible Science Editor |
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| Proofing Editorial Director |
Jin-Lei Wang |
| Proofing Editor-in-Chief |
Lian-Sheng Ma |
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