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2026/1/21 6:17:13 | Browse: 0 | 下载: 0
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
40439 |
| 手稿来源省、自治区或特别行政区 |
浙江省 |
| 专业类型 |
消化病理学 |
| 手稿栏目类型 |
文献综述 |
| 文章标题 |
幽门螺杆菌感染、p53缺陷与p16缺失在胃癌代谢重编程中的致癌三角: 机制与治疗策略
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| 手稿来源 |
自由来稿 |
| 所有作者列表 |
戴健, 周密, 吕键宇, 夏雯慧, 李小兵 |
| 基金项目及其编号 |
| 基金项目名称 |
基金编号 |
| 浙江省中医药科技计划项目 |
2021ZQ086 |
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| 通讯作者 |
李小兵, 博士, 主任医师, 314200, 平湖市当湖街道三港路500号, 平湖市第一人民医院消化内科. lixiaobing750529@163.com |
| 关键词 |
胃癌; 幽门螺杆菌; 代谢重编程; TP53; CDKN2A |
| 核心内容提要 |
本文首次提出“幽门螺杆菌(Helicobacter pylori, H. pylori)感染、p53缺陷与p16缺失”构成“致癌三角”, 系统阐述三者通过协同驱动代谢重编程(如Warburg效应与谷氨酰胺成瘾)促进胃癌(gastric cancer, GC)发生. 该机制整合微生物、遗传与代谢维度, 为靶向干预(如H. pylori根除联合代谢抑制剂)提供新策略, 推动GC治疗向多靶点精准模式转变. |
| 引文著录 |
戴健, 周密, 吕键宇, 夏雯慧, 李小兵. 幽门螺杆菌感染、p53缺陷与p16缺失在胃癌代谢重编程中的致癌三角: 机制与治疗策略. 世界华人消化杂志 2026 |
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Received |
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2025-11-24 12:34 |
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Peer-Review Started |
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2025-11-25 05:37 |
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To Make the First Decision |
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Return for Revision |
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2026-01-09 10:20 |
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修回稿 |
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2026-01-14 12:12 |
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Second Decision |
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2026-01-19 03:21 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2026-01-21 06:17 |
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预出版 |
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2026-01-21 06:17 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| Assistant Editor |
吴云晓健 |
| Science Editor |
刘继红 |
| 评议人编号 |
03018869, 03228365, and 03755444 |
| Editorial Director |
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| Journal Chief Editor |
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| Company Chief Editor |
樊佳茹 |
| Language Editor |
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| Production Editor |
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| Responsible Production Editor |
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| Responsible Science Editor |
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| Proofing Editorial Director |
Jin-Lei Wang |
| Proofing Editor-in-Chief |
Lian-Sheng Ma |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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