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Publication Name 世界华人消化杂志
手稿编号 40500
手稿来源省、自治区或特别行政区 上海市
专业类型 消化内科学
手稿栏目类型 临床研究
文章标题 慢性胰腺炎胰酶替代治疗现状及危险因素分析
手稿来源 自由来稿
所有作者列表 戴璨璨, 刘淼, 张嵩林, 徐金杰, 周筱雨, 杨帆, 姜凌莹, 胡良皞, 刘翠
基金项目及其编号
基金项目名称 基金编号
上海申康医院发展中心新兴前沿项目 SHDC12021107
国家自然科学基金资助项目 82570769
通讯作者 刘翠, 博士, 副教授, 副主任护师, 200433, 上海市杨浦区长海路168号, 海军军医大学第一附属医院消化内科. cuiinliu1228@163.com
关键词 胰酶替代治疗; 慢性胰腺炎; 药物依从; 现状调查; 危险因素
核心内容提要 本研究纳入344例慢性胰腺炎(chronic pancreatitis, CP)患者, 评估胰酶替代治疗(pancreatic enzyme replacement therapy, PERT)依从性及危险因素. 结果显示仅47.38%患者长期坚持服药, 依从性现状不佳. 多因素分析发现, 胆总管狭窄是PERT依从性良好的独立危险因素(OR = 0.059, P = 0.007), 而PPH为保护因素[比值比(odds ratio, OR) = 30.553, P = 0.022]. 提示临床需加强CP患者用药监测与个体化干预, 以改善CP患者PERT依从性及长期预后.
引文著录 戴璨璨, 刘淼, 张嵩林, 徐金杰, 周筱雨, 杨帆, 姜凌莹, 胡良皞, 刘翠. 慢性胰腺炎胰酶替代治疗现状及危险因素分析. 世界华人消化杂志 2026
Received
2026-04-01 09:24
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2026-04-02 08:11
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2026-04-09 09:09
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2026-04-14 13:03
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2026-04-23 08:00
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2026-04-24 11:33
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2026-04-24 11:33
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ISSN 1009-3079 (print) and 2219-2859 (online)
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