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Publication Name 世界华人消化杂志
手稿编号 40675
手稿来源省、自治区或特别行政区 上海市
专业类型 消化内科学
手稿栏目类型 述评
文章标题 急性肝衰竭发病机制研究进展: 从肝细胞死亡与再生失衡到免疫炎症网络紊乱和代谢重编程
手稿来源 约稿
所有作者列表 李玎嘉, 边姝, 刘亮明
基金项目及其编号
通讯作者 刘亮明, 博士, 主任医师, 201600, 上海市松江区中山中路746号, 上海交通大学医学院附属松江医院感染科. 734000110@shsmu.edu.cn
关键词 急性肝衰竭; 发病机制; 细胞死亡; 免疫炎症; 代谢重编程
核心内容提要 急性肝衰竭(acute liver failure, ALF)并非单纯的肝细胞死亡事件, 而是急性损伤后肝细胞死亡与再生失衡、免疫炎症网络紊乱和代谢重编程相互放大的复杂病理过程. 系统梳理多种程序性细胞死亡方式、固有和适应性免疫失衡以及物质和能量代谢异常之间的联系, 有助于发现ALF的关键病理节点和潜在干预靶点.
引文著录 李玎嘉, 边姝, 刘亮明. 急性肝衰竭发病机制研究进展: 从肝细胞死亡与再生失衡到免疫炎症网络紊乱和代谢重编程. 世界华人消化杂志 2026
Received
2026-07-09 12:13
Peer-Review Started
2026-07-13 10:08
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Return for Revision
2026-08-14 08:26
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2026-08-21 07:45
Second Decision
2026-09-28 07:19
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2026-10-09 12:05
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2026-10-09 12:05
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ISSN 1009-3079 (print) and 2219-2859 (online)
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