Publication Name	世界华人消化杂志
手稿编号	38131
手稿来源省、自治区或特别行政区	湖北省

Received	2021-01-21 00:47
Peer-Review Started	2021-01-21 01:21
To Make the First Decision
Return for Revision	2021-02-16 04:54
修回稿	2021-02-25 03:18
Second Decision	2021-03-13 13:42
期刊总编辑接受
公司总编辑接受	2021-03-15 19:21
预出版	2021-03-15 19:21
缴纳版面费
Edit the Manuscript by Language Editor
排版	2021-04-28 10:58
在线出版	2021-04-28 13:23

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化内科学
手稿栏目类型	基础研究
文章标题	miR‐484通过靶向SIRT1介导细胞凋亡参与非酒精性脂肪肝性肝病损伤
手稿来源	自由来稿
所有作者列表	贾银钊, 枚巧娟, 张勇
基金项目及其编号	基金项目名称 基金编号 国家自然科学基金面上项目 No. 81570566
通讯作者	张勇, 博士, 研究生, 教授, 主任医师, 430022, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue,Wuhan, 430022, China, 武汉协和医院肝胆外科. mailzhangyong@126.com
关键词	非酒精性脂肪肝性肝病疾病; miR-484; NAD-依赖性去乙酰化酶Sirtuin-1; 脂肪变性; 细胞凋亡
核心内容提要	近年来, miR-484在调控肿瘤缺氧微环境(肺癌、乳腺癌、结直肠癌、胃癌、肝癌、胰腺癌等)中发挥重要作用, 但目前对miR-484是否参与NAFLD损伤作用机制国内外均尚无相关研究报道. 本研究通过建立小鼠和细胞高脂模型发现: miR‐484通过下调SIRT1表达, 诱导细胞凋亡加重非酒精性脂肪肝损伤. 降低miR-484表达或者上调SIRT1表达能够通过抑制细胞凋亡减轻非酒精性脂肪肝损伤, 为预防或治疗NAFLD损伤提供新的靶点.
出版日期	2021-04-28 13:23
引文著录	贾银钊, 枚巧娟, 张勇. miR‐484通过靶向SIRT1介导细胞凋亡参与非酒精性脂肪肝性肝病损伤. 世界华人消化杂志 2021; 29(8): 389-397
URL	https://www.wjgnet.com/1009-3079/full/v29/i8/389.htm
DOI	https://dx.doi.org/10.11569/wcjd.v29.i8.389

Full Article (PDF)	WCJD-29-389.pdf
审稿意见	WCJD-38131-Peer-review(s).pdf
科学编辑工作清单	WCJD-38131-Scientific editor work list.pdf