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2025/5/28 14:56:38 | Browse: 37 | 下载: 29
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
40240 |
| 手稿来源省、自治区或特别行政区 |
上海市 |
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Received |
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2025-03-27 05:07 |
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2025-03-28 00:42 |
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2025-04-21 03:25 |
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2025-05-08 00:30 |
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2025-05-08 01:10 |
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2025-05-08 01:10 |
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排版 |
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2025-05-27 23:15 |
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在线出版 |
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2025-05-28 09:53 |
| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| 专业类型 |
消化内科学 |
| 手稿栏目类型 |
述评 |
| 文章标题 |
肠道菌群破坏肠道黏膜屏障调控代谢相关脂肪性肝病炎症、免疫与代谢紊乱的研究进展
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| 手稿来源 |
约稿 |
| 所有作者列表 |
吴松婷, 鲁晓岚 |
| 基金项目及其编号 |
| 基金项目名称 |
基金编号 |
| 国家自然科学基金 |
8247030398 |
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| 通讯作者 |
鲁晓岚, 博士, 教授, 主任医师, 201399, 上海市浦东新区拱为路2800号, 上海市浦东医院消化内科. xiaolan_lu@163.com |
| 关键词 |
代谢相关脂肪性肝病; 肠道菌群; 肠道黏膜屏障; 肝脏炎症; 免疫反应; 代谢紊乱; 肠肝轴 |
| 核心内容提要 |
肠道菌群参与肠道黏膜屏障甚或血管屏障的修复与损伤, 一旦某些因素, 如高脂饮食存在等使屏障易于破坏, 细菌及其代谢产物就可通过肠肝轴易位至肝脏, 激活肝脏免疫系统, 进而触发一系列炎症反应, 推动代谢相关脂肪性肝病发生进展. 明确肠道菌群对肠道黏膜甚或血管屏障的破坏作用及其对肝脏炎症、免疫反应和能量的调控作用, 有助于为代谢相关脂肪性肝病的肠肝轴发病机制提供较多思路和证据. |
| 出版日期 |
2025-05-28 09:53 |
| 引文著录 |
吴松婷, 鲁晓岚. 肠道菌群破坏肠道黏膜屏障调控代谢相关脂肪性肝病炎症、免疫与代谢紊乱的研究进展. 世界华人消化杂志 2025; 33(5): 337-343 |
| URL |
https://www.wjgnet.com/1009-3079/full/v33/i5/337.htm |
| DOI |
https://dx.doi.org/10.11569/wcjd.v33.i5.337 |
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