Publication Name	世界华人消化杂志
手稿编号	40635
手稿来源省、自治区或特别行政区	陕西省

Received	2026-06-04 09:14
Peer-Review Started	2026-06-05 06:04
To Make the First Decision
Return for Revision	2026-07-03 12:43
修回稿	2026-07-10 03:45
Second Decision	2026-07-30 08:37
期刊总编辑接受
公司总编辑接受	2026-08-06 03:33
预出版	2026-08-06 03:33
缴纳版面费
Edit the Manuscript by Language Editor
排版	2026-10-25 00:44
在线出版	2026-10-28 08:25

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化肿瘤学
手稿栏目类型	文献综述
文章标题	C2H2型锌指蛋白在肝细胞癌发生发展中的作用
手稿来源	约稿
所有作者列表	王怡恺, 党双锁
基金项目及其编号	基金项目名称 基金编号 四大慢病重大专项 2024ZD0526200
通讯作者	党双锁, 博士, 教授, 主任医师, 710004, 陕西省西安市新城区西五路157号, 西安交通大学第二附属医院感染科. dang212@126.com
关键词	肝细胞癌; C2H2型锌指蛋白; 生物标志物; 诊断; 预后
核心内容提要	锌指蛋白(zinc finger proteins, ZNF)在肝细胞癌(hepatocellular carcinoma, HCC)发生发展中具有显著的双重性. 当前研究热点已从单纯识别异常表达, 转向机制干预: 即靶向抑制促癌ZNF, 或恢复抑癌ZNF功能. 未来趋势是开发基于ZNFs的联合疗法, 以克服肿瘤耐药性, 实现HCC的精准诊断和治疗.
出版日期	2026-10-28 08:25
引文著录	王怡恺, 党双锁. C2H2型锌指蛋白在肝细胞癌发生发展中的作用. 世界华人消化杂志 2026; 34(10): 783-790
URL	https://www.wjgnet.com/1009-3079/full/v34/i10/783.htm
DOI	https://dx.doi.org/10.11569/wcjd.v34.i10.783

Full Article (PDF)	WCJD-34-783-with-cover.pdf
审稿意见	WCJD-40635-Peer-review(s).pdf
科学编辑工作清单	WCJD-40635-Scientific editor work list.pdf