Publication Name	世界华人消化杂志
手稿编号	40674
手稿来源省、自治区或特别行政区	北京市

Received	2026-06-25 09:26
Peer-Review Started	2026-06-26 06:06
To Make the First Decision
Return for Revision	2026-08-14 08:51
修回稿	2026-08-17 09:02
Second Decision	2026-08-27 03:43
期刊总编辑接受
公司总编辑接受	2026-09-01 11:04
预出版	2026-09-01 11:04
缴纳版面费
Edit the Manuscript by Language Editor
排版	2026-10-25 01:08
在线出版	2026-10-28 08:25

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
版权	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
网址	http://www.wjgnet.com

专业类型	消化内科学
手稿栏目类型	述评
文章标题	人工肝治疗肝衰竭的困境与突破
手稿来源	约稿
所有作者列表	徐曼曼, 陈煜
基金项目及其编号	基金项目名称 基金编号 首都卫生发展科研专项项目 No. 首发2026-4-1156
通讯作者	陈煜, 博士, 主任医师, 100069, 北京市丰台区右安门外西头条8号院，北京　100069, 首都医科大学附属北京佑安医院肝病中心四科. chybeyond1071@ccmu.edu.cn
关键词	生物人工肝; 非生物人工肝; 肝衰竭; hiHep; 肝脏类器官; 转基因猪肝
核心内容提要	人工肝已从单纯血液净化迈向生物功能重建. 非生物型仅能清除毒素, 无法恢复肝脏核心功能, 疗效受限. 生物人工肝依托肝细胞、类器官重建肝活性, 早期产品证实可行, 但存在细胞、装置、适应症短板. 多款新型生物人工肝已开展临床验证, 迈入转化阶段, 未来需攻克标准化细胞、全血兼容装置及一体化治疗评价体系.
出版日期	2026-10-28 08:25
引文著录	徐曼曼, 陈煜. 人工肝治疗肝衰竭的困境与突破. 世界华人消化杂志 2026; 34(10): 759-763
URL	https://www.wjgnet.com/1009-3079/full/v34/i10/759.htm
DOI	https://dx.doi.org/10.11569/wcjd.v34.i10.759

Full Article (PDF)	WCJD-34-759-with-cover.pdf
审稿意见	WCJD-40674-Peer-review(s).pdf
科学编辑工作清单	WCJD-40674-Scientific editor work list.pdf