Publication Name	世界华人消化杂志
手稿编号	40201
手稿来源省、自治区或特别行政区	浙江省

Received	2025-02-27 04:43
Peer-Review Started	2025-03-05 01:17
To Make the First Decision
Return for Revision	2025-04-15 01:53
修回稿	2025-04-16 08:28
Second Decision	2025-05-07 09:06
期刊总编辑接受
公司总编辑接受	2025-05-08 02:00
预出版	2025-05-08 02:00
缴纳版面费
Edit the Manuscript by Language Editor
排版	2025-05-27 23:11
在线出版	2025-05-28 09:53

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化基础研究
手稿栏目类型	基础研究
文章标题	荷花碱通过抑制氧化应激与炎症反应减轻酒精诱导的小鼠肝损伤
手稿来源	自由来稿
所有作者列表	蘧小红, 刘晓君
基金项目及其编号
通讯作者	蘧小红, 本科, 主管技师, 321200, 武义第一人民医院检验科, 武义第一人民医院检验科. 13566939720@163.com
关键词	荷花碱; 酒精性肝损伤; 氧化应激; 炎症反应; Nrf-2/HO-1; NF-κB
核心内容提要	荷花碱(neferine, NeF)作为一种有效的抗氧化剂和抗炎剂, 可以抑制酒精性肝损伤(alcoholic liver injury, ALI)小鼠肝脏中的氧化和炎症现象. 尽管本研究揭示了NeF的多重保护机制, 仍需进一步探讨其生物利用度及组织特异性分布. 未来研究可结合基因敲除模型验证关键信号节点的作用, 并通过结构修饰优化其药代动力学特性, 为其在ALI临床应用奠定基础.
出版日期	2025-05-28 09:53
引文著录	蘧小红, 刘晓君. 荷花碱通过抑制氧化应激与炎症反应减轻酒精诱导的小鼠肝损伤.世界华人消化杂志 2025; 33(5): 389-396
URL	https://www.wjgnet.com/1009-3079/full/v33/i5/389.htm
DOI	https://www.wjgnet.com/1009-3079/full/v33/i5/389.htm

审稿意见	WCJD-40201-Peer-review(s).pdf
科学编辑工作清单	WCJD-40201-Scientific editor work list.pdf