BPG致力于知识发现和传播
            
            
                
                
                    
    Featured Articles
    
        2025/8/28 11:56:02 | Browse: 82 | 下载: 75
    
    
        
            
                | Publication Name | 世界华人消化杂志 | 
            
                | 手稿编号 | 40291 | 
            
                | 手稿来源省、自治区或特别行政区 | 天津市 | 
        
        
    
        | 
                
                    |  | Received |  | 2025-05-20 02:25 | 
    
        | 
                
                    |  | Peer-Review Started |  | 2025-05-20 09:13 | 
    
        | 
                
                    |  | To Make the First Decision |  |  | 
    
        | 
                
                    |  | Return for Revision |  | 2025-06-20 01:45 | 
    
        | 
                
                    |  | 修回稿 |  | 2025-06-24 10:04 | 
    
        | 
                
                    |  | Second Decision |  | 2025-08-13 07:49 | 
    
        | 
                
                    |  | 期刊总编辑接受 |  |  | 
    
        | 
                
                    |  | 公司总编辑接受 |  | 2025-08-18 01:22 | 
    
        | 
                
                    |  | 预出版 |  | 2025-08-18 01:22 | 
    
        | 
                
                    |  | 缴纳版面费 |  |  | 
    
        | 
                
                    |  | Edit the Manuscript by Language Editor |  |  | 
    
        | 
                
                    |  | 排版 |  | 2025-08-28 00:51 | 
            
                | 
                        
                            |  | 在线出版 |  | 2025-08-28 11:44 | 
        
        
            
                | ISSN | 1009-3079 (print) and 2219-2859 (online) | 
            
                | 开放获取 | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | 
            
                | 版权 | ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | 网址 | http://www.wjgnet.com | 
        
    
        | 专业类型 | 消化内科学 | 
    
        | 手稿栏目类型 | 文献综述 | 
    
        | 文章标题 | 巴雷特食管致病因素与相关信号转导通路的研究进展 | 
    
        | 手稿来源 | 自由来稿 | 
    
        | 所有作者列表 | 李思琪, 杨磊, 李培彩, 弓艳霞 | 
    
        | 基金项目及其编号 |  | 
    
        | 通讯作者 | 弓艳霞, 博士, 主任医师, 300100, 南开三纬路122号, 天津市南开医院消化内科. gong_yanxia@aliyun.com | 
    
        | 关键词 | 巴雷特食管; 发病机制; 信号转导通路; 致病因素 | 
    
        | 核心内容提要 | 巴雷特食管为胃食管反流病常见的并发症之一, 因其显著的食管腺癌转化风险, 始终是临床与科研领域的焦点. 其病理演变涉及食管鳞状上皮被异常柱状上皮取代, 部分患者还伴随肠上皮化生, 这一过程的分子机制极为复杂, 涵盖多条信号传导通路的异常激活与调控失衡. 近年来在细胞分子生物学层面的研究不断深入, 但确切的发病机制仍存在诸多未知领域. 目前对于巴雷特食管的防治, 部分中药复方或单体成分经临床实践与基础研究证实, 能够有效抑制柱状上皮化生进程, 甚至逆转早期病变, 现阐述巴雷特食管的发病机制, 深入分析所涉及的包含胃酸与胆汁酸为主的致病因素, 及包含炎症与化生相关的分子信号通路, 为未来研制有效的化学预防药物提供线索. | 
            
                | 出版日期 | 2025-08-28 11:44 | 
    
        | 引文著录 | 李思琪, 杨磊, 李培彩, 弓艳霞. 巴雷特食管致病因素与相关信号转导通路的研究进展. 世界华人消化杂志 2025; 33(8): 619-624 | 
            
                | URL | https://www.wjgnet.com/1009-3079/full/v33/i8/619.htm | 
            
                | DOI | https://dx.doi.org/10.11569/wcjd.v33.i8.619 | 
    
    
                
        
     
 
                 
             
         
        
    
        
        
            © 2004-2022 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
            California Corporate Number: 3537345