Publication Name	世界华人消化杂志
手稿编号	40548
手稿来源省、自治区或特别行政区	上海市

Received	2026-04-02 09:15
Peer-Review Started	2026-04-03 01:02
To Make the First Decision
Return for Revision	2026-05-01 09:49
修回稿	2026-05-06 13:36
Second Decision	2026-05-20 06:38
期刊总编辑接受
公司总编辑接受	2026-05-25 11:52
预出版	2026-05-25 11:52
缴纳版面费
Edit the Manuscript by Language Editor
排版	2026-07-20 02:39
在线出版	2026-07-22 01:52

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
版权	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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专业类型	消化影像学
手稿栏目类型	述评
文章标题	CAFs塑造耐药微环境: 消化道肿瘤治疗壁垒的多维机制与破解策略
手稿来源	约稿
所有作者列表	汪晓宇, 任刚
基金项目及其编号
通讯作者	任刚, 博士, 主任医师, 200092, 杨浦区控江路1665号, 上海交通大学医学院附属新华医院放射科. rengang527@163.com
关键词	癌症相关成纤维细胞; 消化道肿瘤; 肿瘤微环境; 治疗耐药; 异质性; 基质屏障; 代谢重编程; 免疫抑制; 外泌体; 靶向治疗
核心内容提要	本文系统综述癌症相关成纤维细胞(cancer-associated fibroblasts, CAFs)的异质性分型及其在食管癌、胃癌、结直肠癌和胰腺癌等消化道肿瘤中的耐药机制, 并总结直接清除、功能重编程、基质正常化、联合用药及外泌体阻断等靶向CAFs的转化研究策略, 为突破消化道肿瘤治疗瓶颈提供理论依据.
出版日期	2026-07-22 01:52
引文著录	汪晓宇, 任刚. CAFs塑造耐药微环境: 消化道肿瘤治疗壁垒的多维机制与破解策略. 世界华人消化杂志 2026; 34(6): 433-442
URL	https://www.wjgnet.com/1009-3079/full/v34/i6/433.htm
DOI	https://dx.doi.org/10.11569/wcjd.v34.i6.433

Full Article (PDF)	WCJD-34-433-with-cover.pdf
审稿意见	WCJD-40548-Peer-review(s).pdf
科学编辑工作清单	WCJD-40548-Scientific editor work list.pdf