Publication Name	世界华人消化杂志
手稿编号	40566
手稿来源省、自治区或特别行政区	广东省

Received	2026-04-10 08:39
Peer-Review Started	2026-04-14 06:11
To Make the First Decision
Return for Revision	2026-05-01 09:17
修回稿	2026-05-06 11:17
Second Decision	2026-05-09 02:25
期刊总编辑接受
公司总编辑接受	2026-05-10 09:21
预出版	2026-05-10 09:21
缴纳版面费
Edit the Manuscript by Language Editor
排版	2026-05-19 06:23
在线出版	2026-05-20 02:34

ISSN	1009-3079 (print) and 2219-2859 (online)
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专业类型	消化内科学
手稿栏目类型	文献综述
文章标题	MASLD进程中肝星状细胞代谢重构与表观遗传记忆
手稿来源	约稿
所有作者列表	邓紫莹, 黄妙灵, 刘序友
基金项目及其编号
通讯作者	刘序友, 博士, 主任医师, 524023, 广东省湛江市霞山区文明东路2号, 广东医科大学第一临床医学院消化内科. liuxy717@163.com
关键词	代谢功能障碍相关脂肪性肝病; 肝星状细胞; 代谢重构; ACLY/ACSS2轴; 表观遗传记忆; 纤维化逆转; 纳米靶向递送
核心内容提要	肝星状细胞(hepatic stellate cell, HSC)的活化及其导致的纤维化, 是代谢功能障碍相关脂肪性肝病(metabolic dysfunction-associated steatotic liver disease, MASLD)向肝硬化演变的核心. 近年的研究明确了HSC活化不仅是细胞形态的变化, 更本质上是代谢模式的切换(如乙酸代谢轴的驱动)以及由此引发的长期“致病记忆”. 虽然空间组学技术让我们了解不同位置的HSC具有不同的功能, 且针对特定代谢酶或修饰酶的新型抑制剂已在动物实验中初显成效, 但临床转化仍面临重重挑战. 通过多学科交叉手段深入解析HSC的调控网络, 将为MASLD相关肝纤维化的防治带来新希望.
出版日期	2026-05-20 02:34
引文著录	邓紫莹, 黄妙灵, 刘序友. MASLD进程中肝星状细胞代谢重构与表观遗传记忆. 世界华人消化杂志 2026; 34(4): 295-301
URL	https://www.wjgnet.com/1009-3079/full/v34/i4/295.htm
DOI	https://dx.doi.org/10.11569/wcjd.v34.i4.295

Full Article (PDF)	WCJD-34-295-with-cover.pdf
审稿意见	WCJD-40566-Peer-review(s).pdf
科学编辑工作清单	WCJD-40566-Scientific editor work list.pdf