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2019/5/10 6:53:51 | Browse: 701 | 下载: 713
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
36678 |
| 手稿来源省、自治区或特别行政区 |
浙江省 |
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Received |
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2018-12-27 07:39 |
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Peer-Review Started |
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2018-12-28 02:49 |
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To Make the First Decision |
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2019-01-30 00:34 |
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Return for Revision |
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2019-01-30 06:52 |
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修回稿 |
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2019-03-26 07:33 |
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Second Decision |
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2019-04-12 07:52 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2019-04-16 22:15 |
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预出版 |
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2019-04-16 22:15 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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2019-05-08 04:03 |
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在线出版 |
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2019-05-10 06:53 |
| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| 专业类型 |
消化基础研究 |
| 手稿栏目类型 |
基础研究 |
| 文章标题 |
miR-20b通过抑制JAK/STAT3信号通路逆转结肠癌细胞5-FU耐药性的研究
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| 手稿来源 |
自由来稿 |
| 所有作者列表 |
余灵芝, 戴丹平, 项秀瑶 |
| ORCID |
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| 基金项目及其编号 |
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| 通讯作者 |
余灵芝, 本科, N/A, 317000, 浙江省台州市临海回浦路92号, 台州恩泽医疗中心(集团)台州医院药剂科. yulingzhittyy@163.com |
| 关键词 |
结肠癌; 5-氟尿嘧啶; 耐药性; miR-20b; Janus激酶/信号转导与转录激活子信号通路 |
| 核心内容提要 |
结肠癌的复发转移及化疗耐药直接影响结直肠癌患者寿命, 越来越多的研究提示miRNA参与了结肠癌的耐药过程. 在本研究中, 我们对miR-20b在结肠癌细胞耐药中的作用进行了探讨. 相比于普通结肠癌细胞, 耐药细胞系细胞中miR-20b表达水平明显下调. 我们的结果表明耐药细胞系细胞对5-氟尿嘧啶的耐药性可由miR-20b介导, 其机制与Janus激酶/信号转导与转录激活子信号通路表达下调相关. |
| 出版日期 |
2019-05-10 06:53 |
| 引文著录 |
余灵芝, 戴丹平, 项秀瑶. miR-20b通过抑制JAK/STAT3信号通路逆转结肠癌细胞5-FU耐药性的研究. 世界华人消化杂志 2019 |
| URL |
https://www.wjgnet.com/1009-3079/full/v27/i9/544.htm |
| DOI |
https://dx.doi.org/10.11569/wcjd.v27.i9.544 |
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