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2019/7/28 10:50:05 | Browse: 558 | 下载: 592
Publication Name 世界华人消化杂志
手稿编号 36964
手稿来源省、自治区或特别行政区 浙江省
Received
2019-04-17 05:55
Peer-Review Started
2019-04-17 07:01
To Make the First Decision
2019-05-14 08:58
Return for Revision
2019-05-20 03:04
修回稿
2019-06-11 06:36
Second Decision
2019-06-27 03:57
期刊总编辑接受
公司总编辑接受
2019-07-15 22:00
预出版
2019-07-15 22:00
缴纳版面费
Edit the Manuscript by Language Editor
排版
2019-07-26 06:45
在线出版
2019-07-28 10:50
ISSN 1009-3079 (print) and 2219-2859 (online)
开放获取 This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
版权 © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
网址 http://www.wjgnet.com
专业类型 消化基础研究
手稿栏目类型 基础研究
文章标题 下调MiR-221对胃癌顺铂耐药细胞增殖及顺铂敏感性的影响及其相关机制
手稿来源 自由来稿
所有作者列表 徐丽娜, 金莉娜
ORCID
作者 ORCID Number
徐丽娜 http://orcid.org/0000-0002-8333-0683
基金项目及其编号
通讯作者 徐丽娜, 本科, N/A, 317000, 台州恩泽医疗中心(集团)台州医院药剂科. xulina362@163.com
关键词 胃癌; 增殖; 顺铂; 化疗敏感性
核心内容提要 microRNA-221(miR-221)在胃癌(Gastric cancer, GC)耐药组织和GC顺铂(Cisplatin, DDP)耐药细胞中显著高表达. 下调miR-221表达抑制GC耐药细胞增殖并促进其对DDP的化学敏感性. 本研究发现, CCND1为GC中miR-221的直接靶基因, 下调miR-221通过抑制CCND1发挥逆转GC DDP耐药的作用, 为抗GC DDP化疗耐药的研究提供了参考.
出版日期 2019-07-28 10:50
引文著录 徐丽娜, 金莉娜. 下调MiR-221对胃癌顺铂耐药细胞增殖及顺铂敏感性的影响及其相关机制. 世界华人消化杂志 2019
URL https://www.wjgnet.com/1009-3079/full/v27/i14/857.htm
DOI https://dx.doi.org/10.11569/wcjd.v27.i14.857
Full Article (PDF) WCJD-27-857.pdf
审稿意见 WCJD-36964-Peer-review(s).pdf
科学编辑工作清单 WCJD-36964-Scientific editor work list.pdf