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2019/7/28 10:50:05 | Browse: 558 | 下载: 592
Publication Name |
世界华人消化杂志 |
手稿编号 |
36964 |
手稿来源省、自治区或特别行政区 |
浙江省 |
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Received |
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2019-04-17 05:55 |
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Peer-Review Started |
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2019-04-17 07:01 |
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To Make the First Decision |
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2019-05-14 08:58 |
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Return for Revision |
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2019-05-20 03:04 |
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修回稿 |
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2019-06-11 06:36 |
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Second Decision |
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2019-06-27 03:57 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2019-07-15 22:00 |
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预出版 |
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2019-07-15 22:00 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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2019-07-26 06:45 |
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在线出版 |
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2019-07-28 10:50 |
ISSN |
1009-3079 (print) and 2219-2859 (online) |
开放获取 |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
版权 |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
网址 |
http://www.wjgnet.com |
专业类型 |
消化基础研究 |
手稿栏目类型 |
基础研究 |
文章标题 |
下调MiR-221对胃癌顺铂耐药细胞增殖及顺铂敏感性的影响及其相关机制
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手稿来源 |
自由来稿 |
所有作者列表 |
徐丽娜, 金莉娜 |
ORCID |
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基金项目及其编号 |
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通讯作者 |
徐丽娜, 本科, N/A, 317000, 台州恩泽医疗中心(集团)台州医院药剂科. xulina362@163.com |
关键词 |
胃癌; 增殖; 顺铂; 化疗敏感性 |
核心内容提要 |
microRNA-221(miR-221)在胃癌(Gastric cancer, GC)耐药组织和GC顺铂(Cisplatin, DDP)耐药细胞中显著高表达. 下调miR-221表达抑制GC耐药细胞增殖并促进其对DDP的化学敏感性. 本研究发现, CCND1为GC中miR-221的直接靶基因, 下调miR-221通过抑制CCND1发挥逆转GC DDP耐药的作用, 为抗GC DDP化疗耐药的研究提供了参考. |
出版日期 |
2019-07-28 10:50 |
引文著录 |
徐丽娜, 金莉娜. 下调MiR-221对胃癌顺铂耐药细胞增殖及顺铂敏感性的影响及其相关机制. 世界华人消化杂志 2019 |
URL |
https://www.wjgnet.com/1009-3079/full/v27/i14/857.htm |
DOI |
https://dx.doi.org/10.11569/wcjd.v27.i14.857 |
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