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2020/6/5 8:41:26 | Browse: 510 | 下载: 637
| Publication Name |
世界华人消化杂志 |
| 手稿编号 |
37675 |
| 手稿来源省、自治区或特别行政区 |
福建省 |
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Received |
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2020-04-02 01:02 |
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Peer-Review Started |
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2020-04-02 18:38 |
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To Make the First Decision |
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Return for Revision |
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2020-05-14 21:21 |
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修回稿 |
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2020-05-22 03:38 |
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Second Decision |
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2020-05-27 09:08 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2020-05-28 00:58 |
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预出版 |
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2020-05-28 00:58 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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2020-06-03 09:18 |
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在线出版 |
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2020-06-05 08:41 |
| ISSN |
1009-3079 (print) and 2219-2859 (online) |
| 开放获取 |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| 版权 |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| 网址 |
http://www.wjgnet.com |
| 专业类型 |
消化内科学 |
| 手稿栏目类型 |
述评 |
| 文章标题 |
胰高血糖素样肽-1受体激动剂在代谢性疾病治疗中的应用前景
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| 手稿来源 |
约稿 |
| 所有作者列表 |
张强, 张秀芳, 牛春燕 |
| ORCID |
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| 基金项目及其编号 |
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| 通讯作者 |
牛春燕, 博士, 教授, 主任医师, 211200, 江苏省南京市溧水区崇文路86号, 南京市溧水区人民医院(东南大学附属中大医院溧水分院)消化内科. nchy69@163.com |
| 关键词 |
胰高血糖素样肽-1受体激动剂; 糖尿病; 心血管疾病; 非酒精性脂肪性肝病; 代谢功能障碍性疾病; 应用前景 |
| 核心内容提要 |
胰高血糖素样肽-1受体激动剂(glucagon-like peptide-1 receptor agonists, GLP-1RAs)一种新型葡萄糖依赖性降糖药物, 可通过促进胰岛素分泌, 胰岛β细胞的增殖、抑制其凋亡, 抑制胰高血糖素分泌等有效降低2型糖尿病(type 2 diabetes mellitus, T2DM)患者的血糖水平并维持血糖稳态, 已被广泛应用于糖尿病治疗. 近年研究发现, GLP-1RAs还具有抑制食欲、延缓胃排空、调节血脂代谢、改善心功能、减少肝脏脂肪沉积等多重生物学效应, 可显著改善合并T2DM的肥胖症及非糖尿病的单纯性肥胖. 以上作用为GLP-1RAs在代谢性疾病中的治疗提供了应用前景和方案选择. |
| 出版日期 |
2020-06-05 08:41 |
| 引文著录 |
张强, 张秀芳, 牛春燕. 胰高血糖素样肽-1受体激动剂在代谢性疾病治疗中的应用前景. 世界华人消化杂志 2020 |
| URL |
https://www.wjgnet.com/1009-3079/full/v28/i11/393.htm |
| DOI |
https://dx.doi.org/10.11569/wcjd.v28.i11.393 |
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