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2025/3/28 13:59:14 | Browse: 24 | 下载: 25
Publication Name |
世界华人消化杂志 |
手稿编号 |
40184 |
手稿来源省、自治区或特别行政区 |
山东省 |
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Received |
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2025-02-08 07:14 |
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Peer-Review Started |
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2025-02-08 15:14 |
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To Make the First Decision |
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Return for Revision |
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2025-03-05 08:38 |
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修回稿 |
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2025-03-10 00:43 |
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Second Decision |
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2025-03-13 06:01 |
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期刊总编辑接受 |
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公司总编辑接受 |
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2025-03-16 06:29 |
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预出版 |
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2025-03-16 06:29 |
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缴纳版面费 |
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Edit the Manuscript by Language Editor |
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排版 |
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2025-03-28 03:50 |
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在线出版 |
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2025-03-28 13:59 |
ISSN |
1009-3079 (print) and 2219-2859 (online) |
开放获取 |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
版权 |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
网址 |
http://www.wjgnet.com |
专业类型 |
消化内科学 |
手稿栏目类型 |
述评 |
文章标题 |
嘌呤能P2X7受体与结-直肠癌相关性研究进展与前景
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手稿来源 |
约稿 |
所有作者列表 |
池肇春 |
ORCID |
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基金项目及其编号 |
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通讯作者 |
池肇春, 本科, 教授, 266011, 山东省青岛市胶州路1号, 青岛市市立医院消化内科. czchow123@163.com |
关键词 |
P2X7R; 结-直肠癌; 肿瘤微环境; 信号传导; 肠道菌群; 先天免疫异常; 治疗靶点 |
核心内容提要 |
结-直肠癌是全球第三大常见癌症. 研究显示嘌呤能P2X7受体(purinergic P2X7 receptor, P2X7R)与结-直肠癌(colorectal cancer, CRC)的发生、进展、转移和预后相关. 尽管人们努力开发有效的结直肠癌治疗方法, 但转移性结直肠癌患者的5年相对生存率仅为14%. 动物实验研究显示, P2X7R拮抗剂治疗 CRC可降低抗癌药物的耐药性、降低癌细胞的增殖和转移, 有望成为CRC治疗的新策略. |
出版日期 |
2025-03-28 13:59 |
引文著录 |
池肇春. 嘌呤能P2X7受体与结-直肠癌相关性研究进展与前景. 世界华人消化杂志 2025; 33(3): 169-177 |
URL |
https://www.wjgnet.com/1009-3079/full/v33/i3/169.htm |
DOI |
https://dx.doi.org/10.11569/wcjd.v33.i3.169 |
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