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Publication Name 世界华人消化杂志
手稿编号 40184
手稿来源省、自治区或特别行政区 山东省
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2025-02-08 07:14
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2025-03-28 13:59
ISSN 1009-3079 (print) and 2219-2859 (online)
开放获取 This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
版权 © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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网址 http://www.wjgnet.com
专业类型 消化内科学
手稿栏目类型 述评
文章标题 嘌呤能P2X7受体与结-直肠癌相关性研究进展与前景
手稿来源 约稿
所有作者列表 池肇春
ORCID
作者 ORCID Number
池肇春 http://orcid.org/0000-0003-2875-1204
基金项目及其编号
通讯作者 池肇春, 本科, 教授, 266011, 山东省青岛市胶州路1号, 青岛市市立医院消化内科. czchow123@163.com
关键词 P2X7R; 结-直肠癌; 肿瘤微环境; 信号传导; 肠道菌群; 先天免疫异常; 治疗靶点
核心内容提要 结-直肠癌是全球第三大常见癌症. 研究显示嘌呤能P2X7受体(purinergic P2X7 receptor, P2X7R)与结-直肠癌(colorectal cancer, CRC)的发生、进展、转移和预后相关. 尽管人们努力开发有效的结直肠癌治疗方法, 但转移性结直肠癌患者的5年相对生存率仅为14%. 动物实验研究显示, P2X7R拮抗剂治疗 CRC可降低抗癌药物的耐药性、降低癌细胞的增殖和转移, 有望成为CRC治疗的新策略.
出版日期 2025-03-28 13:59
引文著录 池肇春. 嘌呤能P2X7受体与结-直肠癌相关性研究进展与前景. 世界华人消化杂志 2025; 33(3): 169-177
URL https://www.wjgnet.com/1009-3079/full/v33/i3/169.htm
DOI https://dx.doi.org/10.11569/wcjd.v33.i3.169
Full Article (PDF) WCJD-33-169-with-cover.pdf
审稿意见 WCJD-40184-Peer-review(s).pdf
科学编辑工作清单 WCJD-40184-Scientific editor work list.pdf