Publication Name	世界华人消化杂志
手稿编号	40238
手稿来源省、自治区或特别行政区	江西省

Received	2025-03-24 07:42
Peer-Review Started	2025-03-25 08:36
To Make the First Decision
Return for Revision	2025-04-15 01:41
修回稿	2025-04-25 03:38
Second Decision	2025-05-16 07:24
期刊总编辑接受
公司总编辑接受	2025-05-19 01:32
预出版	2025-05-19 01:32
缴纳版面费
Edit the Manuscript by Language Editor
排版	2025-05-27 23:16
在线出版	2025-05-28 09:53

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化基础研究
手稿栏目类型	文献综述
文章标题	线粒体DNA释放通过激活炎症通路介导代谢相关脂肪性肝炎的研究
手稿来源	自由来稿
所有作者列表	刘莹, 胡杨, 单兆良
ORCID	作者 ORCID Number 刘莹 http://orcid.org/0009-0006-1785-9104 单兆良 http://orcid.org/0009-0009-2325-5093
基金项目及其编号
通讯作者	单兆良, 博士, 讲师, 341000, 贡区高新区武当山路1号, 创新与转化医学研究院学科建设中心. shanzl@gimi.ac.cn
关键词	代谢功能障碍相关脂肪性肝炎; 线粒体DNA; 线粒体DNA释放; cGAS-STING信号轴; Toll样受体9; 炎性小体
核心内容提要	代谢相关脂肪性肝炎(metabolic dysfunction-associated steatohepatitis, MASH)正迅速成为全球健康领域的一个重大挑战. 本文从线粒体DNA的损伤相关分子模式作用、突变和甲基化修饰、释放机制及相关信号通路四个方面总结了其在MASH中的功能和作用机制.
出版日期	2025-05-28 09:53
引文著录	刘莹, 胡杨, 单兆良. 线粒体DNA释放通过激活炎症通路介导代谢相关脂肪性肝炎的研究. 世界华人消化杂志 2025; 33(5): 344-360
URL	https://www.wjgnet.com/1009-3079/full/v33/i5/344.htm
DOI	https://dx.doi.org/10.11569/wcjd.v33.i5.344

Full Article (PDF)	WCJD-33-344-with-cover.pdf
审稿意见	WCJD-40238-Peer-review(s).pdf
科学编辑工作清单	WCJD-40238-Scientific editor work list.pdf