Publication Name	世界华人消化杂志
手稿编号	36408
手稿来源省、自治区或特别行政区	北京市

Received	2018-09-21 09:19
Peer-Review Started	2018-09-22 14:01
To Make the First Decision	2018-10-11 02:56
Return for Revision	2018-10-14 05:36
修回稿	2018-10-23 09:13
Second Decision	2018-11-08 09:34
期刊总编辑接受
公司总编辑接受	2018-11-09 00:18
预出版	2018-11-09 00:18
缴纳版面费
Edit the Manuscript by Language Editor
排版	2019-01-28 11:14
在线出版	2019-01-31 09:08

ISSN	1009-3079 (print) and 2219-2859 (online)
开放获取	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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专业类型	消化基础研究
手稿栏目类型	述评
文章标题	慢加急性肝衰竭研究的新视角: 肝纤维化与损伤抵抗
手稿来源	约稿
所有作者列表	白丽, 陈煜, 段钟平, 郑素军
基金项目及其编号
通讯作者	郑素军, 博士, 教授, 主任医师, 100069, 北京市丰台区右安门外西头条8号, 首都医科大学附属北京佑安医院疑难肝病与人工肝中心. zhengsujun003@126.com
关键词	慢加急性肝衰竭; 肝纤维化; 损伤抵抗; 巨噬细胞活化; 表型转换
核心内容提要	纤维化肝脏中M2-样活化的巨噬细胞发挥着抵抗急性打击的有益肝保护效应, 其作用机制主要包括两个方面: (1)促进介导损伤效应的M1-样巨噬细胞凋亡, 抑制肝细胞凋亡; (2)抑制HMGB1的转位和释放及其介导的促炎免疫反应. 调控巨噬细胞的M1/M2活化有望成为控制慢加急性肝衰竭发展及影响疾病转归的重要策略.
出版日期	2019-01-31 09:08
引文著录	白丽, 陈煜, 段钟平, 郑素军. 慢加急性肝衰竭研究的新视角: 肝纤维化与损伤抵抗. 世界华人消化杂志 2018
URL	https://www.wjgnet.com/1009-3079/full/v27/i3/139.htm
DOI	https://dx.doi.org/10.11569/wcjd.v27.i3.139

Full Article (PDF)	WCJD-27-139.pdf
审稿意见	WCJD-36408-Peer-review(s).pdf
科学编辑工作清单	WCJD-36408-Scientific editor work list.pdf